临床医学理论

考试动态
复习指导
首页 > 临床医学理论 > 学术动态 > 正文

铜在阿尔兹海默症的形成起到重要的作用

——●●●聚焦热点●●●——

报名预约> 有问必答> 报考测评>

近日,来自英国基尔大学的研究者通过研究揭示,铜不仅仅可以帮助个体的大脑抵御β-淀粉样蛋白形成这折叠片,而且铜也直接参与了阿尔兹海默症患者大脑中衰老斑的形成。

研究揭示,大脑中低水平的铜可以促进某种特定机制的发生,这种机制就是在阿尔兹海默症疾病中,β淀粉样蛋白可以以衰老斑的形式存在。

目前研究者研究的重点就是调查是否大脑中的铜可以促使阿尔兹海默症患者大脑中衰老斑的形成,此前研究中,研究者指出,铜的存在可以保护β淀粉样蛋白免于聚集形成折叠片以及形成衰老斑,当然研究者希望通过后期的深入研究来阐明其中所发生的分子机理医`学教育网搜集整理。

该项研究以“Copper prevents amyloid-β1-42 from forming amyloid fibrils under near-physiological conditions in vitro”为题刊登于国际著名杂志杂志Nature的子刊Scientific Reports上。

The aggregation and deposition of amyloid-β(1–42) (Aβ42) in the brain is implicated in the aetiology of Alzheimer's disease (AD)。 While the mechanism underlying its deposition in vivo is unknown its precipitation in vitro is influenced by metal ions. For example, Aβ42 is known to bind copper, Cu(II), in vitro and binding results in aggregation of the peptide. The biophysical properties of Cu(II)-Aβ42 aggregates are of significant importance to their putative involvement in the amyloid cascade hypothesis of AD and are currently the subject of strong debate. In particular the question has been raised if sub- and super-stoichiometric concentrations of Cu(II) act in opposing ways in respectively accelerating and preventing amyloid fibril formation by Aβ42. Herein we have used fluorimetry and transmission electron microscopy to provide unequivocal evidence that under near-physiological conditions both sub- and super-stoichiometric concentrations of Cu(II) prevented the assembly of Aβ4

打开APP看资讯 更多更快更新鲜 >>
精品课程

高效定制班

2025课程

4180

详情>>
取消
复制链接,粘贴给您的好友

复制链接,在微信、QQ等聊天窗口即可将此信息分享给朋友
前往医学教育网APP查看,体验更佳!
取消 前往