从事肿瘤学研究的学者可能都读过他的一篇文章:The Hallmarks of Cancer,这篇综述性文章介绍了肿瘤细胞的六大基本特征,被称为肿瘤学研究的经典论文,到目前为止,这篇论文已经被引用了上万次。
3月新出版的Cell杂志上,Weinberg教授又发表了一篇升级版综述:Hallmarks of Cancer: The Next Generation,这篇同样也是与Douglas Hanahan合作的论文长达29页,简述了最近10年肿瘤学中的热点和进展,包括细胞自噬、肿瘤干细胞、肿瘤微环境等等,并且将原有的肿瘤细胞六大特征扩增到了十个,这十个特征分别是:
自给自足生长信号(Self-Sufficiency in Growth Signals);抗生长信号的不敏感(Insensitivity to Antigrowth Signals);抵抗细胞死亡(Resisting Cell Death);潜力无限的复制能力(Limitless Replicative Potential);持续的血管生成(Sustained Angiogenesis);组织浸润和转移(Tissue Invasion and Metastasis);避免免疫摧毁(Avoiding Immune Destruction);促进肿瘤的炎症(Tumor Promotion Inflammation); 细胞能量异常(Deregulating Cellular Energetics);基因组不稳定和突变(Genome Instability and Mutation)。
6. Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning
Nadya Kondrashov, Aya Pusic, Craig R. Stumpf, Kunihiko Shimizu, Andrew C. Hsieh, Shifeng Xue, Junko Ishijima, Toshihiko Shiroishi, Maria Barna
7. Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10
Peng Cao, Anton Maximov, Thomas C. Südhof
8. A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference
Prem K. Premsrirut, Lukas E. Dow, Sang Yong Kim, Matthew Camiolo, Colin D. Malone, Cornelius Miething, Claudio Scuoppo, Johannes Zuber, Ross A. Dickins, Scott C. Kogan et al.